In 1990, she graduated from Lane Tech and moved to New York City. The experience which she had gained as a performer with the Latino Chicago Theater Company, helped open the doors for her in that city. Soon, she was offered a job as a professional actress in Los Angeles, California. She moved to Los Angeles and in 1996, Machado landed her first two acting roles. She was cast as "Elsa" in the TV series NYPD Blue episode #311, and she was also cast as "Val Cho" in the movie made for television No One Can Tell.

"Six Feet Under"
On June 10, 2001, Machado auditioned for the "new" TV series Six Feet Under and was cast as "Vanessa Diaz", a supporting role character which has evolved into a "regular" character in the series. Machado and her castmates were honored with a Screen Actors Guild Award for "Outstanding Performance by an Ensemble in a Drama Series". The series entered its fifth and final season in 2005. Machado has also appeared in the Canadian television series 1-800-Missing as "Sunny Estrada".

Film roles
Machado has participated in over 14 films. Amongst her most notable roles so far are: "Carmen Rodriguez" in the 1997 film She's So Lovely directed by Nick Cassavetes; a supporting role in Full Frontal (2002); as "Isabella Hudson" in director David R. Ellis' 2003 horror movie Final Destination 2; as "Agent Herderson" in the 2004 thriller Torque starring Ice Cube, Little Fugitive and she is currently cast as "Terressa" in Man Maid which is in its post-production stages and as "Sofia" in The Accidental Husband which is currently being filmed.

Machado has also made appearances on stage. She participated in the productions of Blade to the Heat and Black Butterfly at the Mark Taper Forum in Los Angeles.